Nathan Hughes will start at number eight when England's Six Nations title defence resumes against Scotland at Murrayfield on Saturday.
Hughes has recovered from the knee ligament damage sustained on club duty for Wasps in December and is thrust straight into the back row in the absence of Sam Simmonds, who featured against Italy and Wales.
"Nathan Hughes has worked hard on his fitness. I've never seen him in better physical condition, so we are looking forward to him playing," head coach Eddie Jones said.
Simmonds was withdrawn at half-time of the 12-6 victory over Wales and is expected to miss the remainder of the Six Nations.
Billy Vunipola, first choice in the position, is unavailable because of a broken arm but the Fijian-born Hughes offers similar ball-carrying threat compared to the lighter and more mobile Simmonds.
"Nathan has a key role in defence and in us gaining momentum in attack," Jones said.
Jonathan Joseph has edged Ben Te'o to retain his starting place at outside centre and, apart from Hughes' return, the pack remains the same.
On the bench, Joe Marler replaces Alec Hepburn after serving a six-week ban for a dangerous clear-out and will provide cover for loosehead prop Mako Vunipola, but the replacements otherwise remain unchanged.
James Haskell, also available after completing a ban, has been unable to force his way into the 23.
The 136th Calcutta Cup clash - the game's oldest international fixture - will register milestones for Joe Launchbury and captain Dylan Hartley.
Launchbury is to win his 50th England cap, having made his debut against Fiji in 2012, while Hartley becomes the nation's second most capped player by surpassing the 91-appearance mark set by Jonny Wilkinson.
"For any player to play 50 caps for their country is a wonderful achievement. Joe has worked really hard to improve and is such an important player for us," Jones said.
— England Rugby (@EnglandRugby) February 22, 2018
England team to play Scotland
FORWARDS: 1 Mako Vunipola (Saracens), 2 Dylan Hartley (CAPTAIN, Northampton Saints), 3 Dan Cole (Leicester Tigers), 4 Joe Launchbury (Wasps), 5 Maro Itoje (Saracens), 6 Courtney Lawes (Northampton Saints), 7 Chris Robshaw (Harlequins), 8 Nathan Hughes (Wasps)
BACKS: 9 Danny Care (Harlequins), 10 George Ford (Leicester Tigers), 11 Jonny May (Leicester Tigers), 12 Owen Farrell (Saracens), 13 Jonathan Joseph (Bath Rugby), 14 Anthony Watson (Bath Rugby), 15 Mike Brown (Harlequins)
REPLACEMENTS: 16 Jamie George (Saracens), 17 Joe Marler (Harlequins), 18 Harry Williams (Exeter Chiefs), 19 George Kruis (Saracens), 20 Sam Underhill (Bath Rugby), 21 Richard Wigglesworth (Saracens), 22 Ben Te'o (Worcester Warriors), 23 Jack Nowell (Exeter Chiefs)