Scotland head coach Gregor Townsend will hand a Test debut to Glasgow centre Sam Johnson for the Six Nations opener at home to Italy on Saturday.
Newcastle flanker Gary Graham, previously called up by England coach Eddie Jones, and Leicester hooker Jake Kerr could also win their first caps if they appear off the bench.
Edinburgh full-back Blair Kinghorn, meanwhile, will start on the left wing as the Dark Blues welcome the Azzurri to Murrayfield.
With Edinburgh resurgent under Richard Cockerill this season, Townsend has chosen to go with the capital outfit's tight five. Hooker Stuart McInally will squeeze in between props Allan Dell and WP Nel, with Ben Toolis and Grant Gilchrist forming the second row.
Exeter lock Sam Skinner will slot in to the back-row after showing he can fill in at flanker during his impressive introduction to the national team set-up during the autumn, with Ryan Wilson and Jamie Ritchie completing the back-row.
Skipper Greig Laidlaw will partner Racing 92 star Finn Russell in the half-backs, while Australia-born Johnson - who qualifies on residency grounds after signing for Glasgow in 2015 - lines-up alongside Huw Jones in midfield.
Stuart Hogg will again provide an attacking threat from full-back as he slots in beside Kinghorn - deputising for the injured Sean Maitland - and Tommy Seymour in the back three.
Townsend said: "It's a privilege to be involved in the Guinness Six Nations, a tournament that has grown in quality over the past few seasons. You can sense the excitement throughout the rugby world on the eve of this year's Championship and we're looking forward to our starting our campaign at BT Murrayfield.
"Italy have made life tough for Scotland in every Test match we've played. I remember that as a player, as a supporter and as a coach - and they were better than us in most of last season's contest in Rome. They played with pace, were physical and we had to play really, really well in the final quarter to win.
"That performance and also the recent displays of Benetton Treviso are sharp reminders for our players that this will be a difficult fixture.
"Our challenge is to win the physical battle, which is a strength of Italian rugby. We will also have to bring energy and accuracy in order to get our campaign off to a winning start."
— Scottish Rugby (@Scotlandteam) January 31, 2019
Scotland team to play Italy
Forwards: 1 Allan Dell (Edinburgh), 2 Stuart McInally (Edinburgh), 3 Willem Nel (Edinburgh), 4 Ben Toolis (Edinburgh), 5 Grant Gilchrist (Edinburgh), 6 Sam Skinner (Exeter Chiefs), 7 Jamie Ritchie (Edinburgh), 8 Ryan Wilson (Glasgow Warriors)
Backs: 9 Greig Laidlaw (CAPTAIN, Clermont Auvergne), 10 Finn Russell (Racing 92), 11 Blair Kinghorn (Edinburgh), 12 Sam Johnson (Glasgow Warriors)*, 13 Huw Jones (Glasgow Warriors), 14 Tommy Seymour (Glasgow Warriors), 15 Stuart Hogg (Glasgow Warriors)
Replacements: 16 Jake Kerr (Leicester Tigers)*, 17 Jamie Bhatti (Glasgow Warriors), 18 Simon Berghan (Edinburgh), 19 Gary Graham (Newcastle Falcons)*, 20 Josh Strauss (Sale Sharks), 21 Ali Price (Glasgow Warriors), 22 Adam Hastings (Glasgow Warriors), 23 Chris Harris (Newcastle Falcons)
*Denotes uncapped player